The skin on the face differs from the skin elsewhere on the body.
The top layer of the facial skin(the stratum corneum) is thinner and more delicate than the rest of the skin on the body(except the skin of genitalia).The average thickness of the skin that covers the face is between 0.05 millimetres(around the eyes) and 0.1 millimetres.In comparison, the skin of the palms and soles is around 1.5 millimetres thick.
The number of cells in the skin of the face are fewer than the rest of the body.The cells are smaller and have wider gaps between them, which make facial skin more permeable.
Because facial skin is more often exposed to sunlight,glycation of the skin can occur at a more rapid rate than elsewhere on the body.Glycation is caused by the presence of excess glucose in skin fibres, which cause sugar molecules to adhere to the collagen and elastin proteins that normally keep the skin firm and supple.Glycated collagen becomes stiff and difficult to repair.
Facial skin is more sensitive to hormonal changes.For example androgens can cause the skin on the face to produce more or less sebum through small glands located in each pore of the skin.
The skin of the face has the highest number of sebaceous glands per square inch on the body except for the chest.
There are more blood vessels per square centimetre on the face than anywhere else on the body.In many areas these blood vessels and tiny capillaries are very close to the surface.They increase the ability of the face more prone to conditions such as rosacea and broken capillaries.The number, size and fragility of the smaller capillaries, combined with the thinness of facial skin, present safety issues when needing.